Jimmy Cowan, Akapusi Qera and Billy Twelvetrees are all named in Gloucester's side for the visit of London Irish in the Challenge Cup.
Dan Murphy, Rupert Harden, Will James, Ben Morgan and Rob Cook all start after being replacements last week.
Shane Geraghty comes into the London Irish line-up at fly-half.
Guy Armitage returns at inside centre, Kieran Low starts in the back row and James Sandford partners Bryn Evans in the second row.
VIEWS FROM THE TRAINING GROUND
Gloucester director of rugby Nigel Davies told BBC Points West:
"It's only a job half-done. It was great to comeback in the way we did [in the 29-22 win] but they showed what a dangerous team they are.
"We really weren't at the races in the first half and that was disappointing.
"That's happened a few times this season and so we've got to be very guarded against that.
"But we've got ourselves in a very strong position and we're really looking forward to Saturday."
LINE-UPS
Gloucester: Cook; Sharples, Tindall, Twelvetrees, Monahan; Burns, Cowan; Murphy, Dawidiuk, Harden, James, Hamilton (capt), Savage, Qera, Morgan.
Replacements: Britton, Wood, Knight, Kalamafoni, Cox,Robson, Molenaar, Thomas.
London Irish: Homer; Ojo, Joseph, Armitage, Watson; Geraghty, Allinson; Lahiff, Paice, Aulika, Sandford; Evans (capt), Low, Gibson, Hala'ufia.
Replacements: Lawson, Yanuyanutawa, Halavatau, Garvey, Danaher, Tagicakibau, Shingler, Moate.
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