The Royals have already picked up wins against Peterborough and QPR in this year's competition, but will have to step it up a gear to overcome Arsene Wenger's men.
An inexperienced Arsenal side thrashed Coventry 6-1 in that last round, and can be backed at 10/11 (1.91) to send their opponents packing at the Madejski Stadium.
After three draws in the last four games for Brian McDermott's men, odds of 5/2 (3.50) might seem tempting on a stalemate taking place after 90 minutes here.
With Wenger sure to ring the changes from the side that beat QPR at the weekend, it is difficult to predict how an unfamiliar Arsenal line-up will fare against Reading's first team.
When you consider that Arsenal's own back-line is likely to feature a couple of rookies, the best bet looks to be on over 2.5 goals going in this evening, available at 4/6 (1.67) odds.
With the regular strikeforce potentially taking a rest, tonight's match could give Theo Walcott the opportunity he so craves to show what he can do up front.
The England international bagged two goals in the rout against Coventry, and offers great value at 23/10 (3.30) to send his manager a message by getting on the scoresheet once again here.
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Al Hain-Cole is a Liverpool fan, experienced tipster and avid follower of European football. He specialises in accumulators and if you would like to read more from Al you can follow him on Twitter here.
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