After winning for a tenth successive game away from home, in Marseille on Wednesday, Arsenal return to the Emirates amd Midfielder Mikel Arteta could return to the squad for the first time this season after a thigh injury.
Santi Cazorla remains sidelined, so record signing Mesut Özil is set for his home debut following his club-record £42 million arrival from Real Madrid.
Czech playmaker Tomas Rosicky is also still out, along with France Under-21 forward Yaya Sanogo, German forward Lukas Podolski and longer-term absentees Alex Oxlade-Chamberlain and Abou Diaby.
Midfielder Charlie Adam has been Stoke's only injury concern ahead of Sunday's game.
The Scotland international needed stitches in a cut after a training ground incident but the Potters expect him to be fit to feature at the Emirates Stadium.
Midfielder Stephen Ireland and forward Mark Arnautovic, who made their debuts off the bench against Manchester City last week, are pushing for first starts.
Aaron Ramsey's trigger-happy start to the season may have grabbed headlines, but it is Mesut Özil who may prove Arsenal's key midfielder here on his home debut.
Mark Hughes has made a quietly impressive start to life at Stoke, who have yet to concede more than once in a game this season.
Özil's rare talent for breaching teak-tough defences will be tested to the full.
Betting: Home 1-3, Away 17-2, Draw 19-5.
Stat of the game: Arsenal have won five out of five home Premier League games against Stoke.
Jonathan Liew's prediction: Arsenal 1 Stoke City 0.